MiniTEM - designed for sub-visible particle characterization

New regulatory requirements demand root cause analysis to understand the impact of changes during process and product development.

Nanoparticles like viruses, VLP particles and adjuvants in the 0.05-0,1 µm size range need to be quantitated, size analyzed and characterized.

MiniTEMTM transmission electron microscope is specifically designed to characterise nano-particles. As a compact low-voltage system, it runs in any laboratory setting. All you need is a standard wall socket. MiniTEMTM includes all the components you expect to find in a quality electron microscope.



Morphology analysis based on automated classification.

Size distribution

MiniTEM can separate particle types based on morphological appearance and provides shape and size distributions of the particles of interest.


Using direct imaging methods helps to assess the level of particle aggregation in a sample. Direct visualization allows differentiation of free versus aggregated particles.

Surface structure

Changes or choices at different steps during process and product development can affect particle surface properties critical for final product efficacy.



Automated to reduce manual operating time.


Automated based on structural characteristics.


Integrated detection of different macro-structures enables per particle analysis.


Visualized live and easily shared in reports.

Traceability and report generation

In addition to the features in MiniTEM you can also use Vironova Analyzer Software (VAS) for your aquired images to get full traceability of all data plus an automated report generator function.


Using MiniTEM in vaccine development

MiniTEM is specifically designed for nanoparticle analysis. It is an affordable, automated and easy-to-use solution that covers the measurement range 0.01 to 10 μm.

MiniTEM material science

Materials science is a complex field of study applying the different properties of matter to various areas of science and engineering. One of the most important tools available to investigate the structure of materials is the TEM.

A comparative study of MiniTEM versus DLS and NTA.

AAV particles contaminated by host cell proteasomes are analysed with direct vs indirect methods performed in a standard laboratory setting to reveal the difference in performance and quality of the information obtained.


Right where you need it

MiniTEM is a system based on the LVEM 25 desk top sized microscope from Delong Instruments a.s. The microscope uses low voltage and can be placed in standard office or GMP-compliant laboratory settings.