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Size distribution analysis

MiniTEM automates imaging, AAV particle detection and measurements to present accurate size distribution data

MiniTEM™ can reveal contaminants in AAV samples, for example proteosomes in the figure below.

Size distribution analysis
Size distribution analysis

In the above graph an overlay of the results from MiniTEM and DLS analysis of the same sample is shown. DLS was in this case not able to distinguish between AAV particles and the proteasomes.

Size distribution study with MiniTEM can also reveal small size debris and aggregates

Level and size of aggregates

The size distribution graph shows the number of particles of expected size as well as smaller size debris and aggregates – the data is easily correlated to what is revealed in the acquired images.