Full or empty analysis

AAV virus capsids and liposomal drugs are analysed by Vironova services using cryo transmission electron microscopy (CryoTEM) which allows the direct visualization of the particles in their native state. Quantitative and reliable assessment of the packaging efficiency of the particles can be performed thanks to Vironova Analyzer software (VAS).

Liposome & LNP based drugs

Packaging efficiency (full/empty ratio)
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VAS software allows objective determination of drug content of liposomes

The VAS software measures whether the liposomes contain the drug or not. The program then presents a bar chart. The output of VAS analysis is a report with quantitative data.

Gene therapy & virus based vaccines

Percentage full AAV capsids
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The VAS software in combination with cryoTEM accurately distinguishes between full and empty AAV particles

Cryo EM Cryo EM graph

The output of VAS analysis is a report with quantitative data.


Cryo EM table



These analyses are part of our standard service offering. Take a closer look at VAS if you have your own acquired TEM images to analyze.

Sample description (optional)

Analysis objective (optional)


Study Proposal Form

Please fill out the following information with as much detail as you can, in order for us to provide you with an accurate quote as soon as possible.

* - Compulsory fields
What is the nature of the product
If relevant, where will the product be marketed
Should the study be performed in compliance with GLP
Should the study be performed in duplicate
Will a representative from your company be present during the testing
Process steps to be tested Model viruses Processing time Number of points for sampling If representative(s) will be present, please specify for which step(s)
Vironova Biosafety
Thank you for your interest.