Particle characteristics such as shape or surface structure, as well as the overall morphology, are often correlated to the efficacy of the end gene therapy drug or vaccine product.
EM is an ideal technology to truly understand the effects on particle morphology when you change your upstream or downstream process or product formulation.
Liposome & LNP based drugs
Shape (circularity) distribution analysis of liposomes detected by VAS
VAS is employed to quantify lamillarity classes
High magnification cryoTEM of liposomes supports measurements of bilayer thickness
The graph shows the thickness distribution in nm.
Gene therapy & virus based vaccines
Examples of details in virus morphology revealed with nsTEM
Influenza virus protein