Particle morphology

Particle characteristics such as shape or surface structure, as well as the overall morphology, are often correlated to the efficacy of the end gene therapy drug or vaccine product.

EM is an ideal technology to truly understand the effects on particle morphology when you change your upstream or downstream process or product formulation. 

Liposome & LNP based drugs

Morphology including circularity
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Shape (circularity) distribution analysis of liposomes detected by VAS

Liposomal lamellarity
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VAS is employed to quantify lamillarity classes

Thickness of liposomal bilayer
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High magnification cryoTEM of liposomes supports measurements of bilayer thickness

The graph shows the thickness distribution in nm.

Gene therapy & virus based vaccines

Detailed virus morphology
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Examples of details in virus morphology revealed with nsTEM


Virus integrity before Virus integrity after
Rotavirus Influenza


Influenza spike proteins

Influenza virus protein


Sample description (optional)

Analysis objective (optional)


Study Proposal Form

Please fill out the following information with as much detail as you can, in order for us to provide you with an accurate quote as soon as possible.

* - Compulsory fields
What is the nature of the product
If relevant, where will the product be marketed
Should the study be performed in compliance with GLP
Should the study be performed in duplicate
Will a representative from your company be present during the testing
Process steps to be tested Model viruses Processing time Number of points for sampling If representative(s) will be present, please specify for which step(s)
Vironova Biosafety
Thank you for your interest.