Liposomal particles for drug delivery
Our analysis services include assessment of quality attributes recommended in regulatory guidelines for drug delivery nanoparticles such as particle size distribution, particle morphology (including shape and lamellar structure), loading efficiency of liposomes (often referred to as ratio of filled vs empty), physical state of the encapsulated drug substance and more.
Cryo-transmission electron microscopy (cryoTEM) combined with image analysis using proprietary Vironova Analyzing Software (VAS) enables reliable quantitative data.
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Size distribution of liposomes detected with VAS
Shape (circularity) distribution analysis of liposomes detected by VAS
VAS software allows objective determination of drug content of liposomes
The VAS software measures whether the liposomes contain the drug or not. The program then presents a bar chart. The output of VAS analysis is a report with quantitative data.
VAS is employed to quantify lamillarity classes
High magnification cryoTEM of liposomes supports measurements of bilayer thickness
The graph shows the thickness distribution in nm.