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Through TEM, we offer deep insights into a variety of properties such as particle morphology, size, aspect ratio, and distribution. We can identify particle types and evaluate their dispersion or aggregation, which is essential for quality control and manufacturing processes. Our services also allow us to assess the product's purity relative to background noise, providing valuable insights into the microstructure and integrity of the materials.


Unleashing the Power of TEM with Vironova: Quality Control at Your Fingertips

Transmission Electron Microscopy (TEM) is not just a tool, but an industry game-changer in the realm of materials science. With TEM, you're not just observing, but delving deep into the heart of your materials, gleaning insights from the macroscopic to sub-atomic levels. This makes TEM instrumental in the innovation of new-age materials and in discerning connections between structural properties and functional performances. From clean energy solutions to forensics, and biopharmaceuticals to nanocomposites, with TEM, you gain crucial product quality insights, empowering you to address analytical challenges and make informed decisions to ensure robust monitoring and control of manufacturing processes.

Redefining Imaging and Analysis for Superior Material Insights

At Vironova, we're not just providing services. We're revolutionizing them. Our EM Services offer a unique blend of qualitative and quantitative data for a comprehensive assessment of your material’s properties. Our AI-based analysis enables us to examine a variety of properties, including particle shape, size, distribution, and microstructure integrity, to ensure the highest standards of product purity. This unbiased classification provides a holistic view of your material, transforming the way you perceive quality control.

Versatility Meets Precision: Materials Suited for TEM Analysis

Our prowess isn't limited. From metals, ceramics, and polymers to composites and biomolecules, our EM Services team at Vironova stands ready to analyze a wide range of materials. The only criterion? These materials should ideally fall within the nm range to facilitate electron beam transmission. This process unveils varied internal contrast densities, enlightening us about the material’s thickness, density, chemical composition, or crystallinity. Our services cater to materials in the form of particles, fibers, and thin films.

Seamless Sample Preparation for TEM: Ensuring Quality and Consistency

At Vironova, we understand that sample preparation is pivotal. Depending on your sample characteristics, we offer either negative stain transmission electron microscopy (nsTEM) or cryogenic transmission electron microscopy (cryo-TEM) analyses. For inorganic materials, we use a simple copper grid deposition and imaging by conventional TEM. For bio-based materials sensitive to the electron beam, either nsTEM or cryo-TEM is used. Our GMP-certified methods ensure consistent quality for reliable results.

TEM: Your Key to Unlocking the Future of Materials Research and Quality Control

Whether it's fundamental materials research or process control, TEM offers broad-scale monitoring capabilities. It helps guide process development and improvement, shrinking the time-to-market and cutting costs. TEM also plays a crucial role in quality control and failure analysis, providing timely defect or impurity detection. This valuable data aids stakeholders in making informed decisions to ensure product safety, efficacy, and consistent quality.

Extensive service portfolio

We offer an extensive service portfolio including a wide range of analyses (marked in red circle) to support your biopharma needs. We can also provide specific analyses tailored to your requirements.

 Type of Material Type of analysis
  Overall morphology Size distribution Packaging Aggregation Circularity Bespoke classification
Metal oxide 


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What type of services do Vironova provide?
we offer a complete TEM analysis package that includes both negative stain TEM (nsTEM) and cryogenic TEM (cryo-TEM). Our analysis reports provide valuable morphological information that is translated into quantitative and qualitative data, allowing for faster and more informed decision-making.

What should I do to start a project with Vironova?
To learn more about our services and how we can assist you in the biopharma industry, please visit our website and fill out the "Send us a request" form, or email us directly at info@vironova.com. One of our team members will promptly contact you to set up a meeting with our experienced scientists who can explain our processes and answer any questions you may have.

What are the different steps in the process at Vironova when you start a project?
Once you have decided to utilize our services, we will begin the project by preparing the necessary documents according to our procedures. Once all documentation is complete, we will notify you that we are ready to receive your samples. Our delivery team will provide guidance to ensure that your samples are properly shipped to us. Our senior scientists in Stockholm will perform the analysis, and the analytical report will be finalized and delivered to you within 10-15 working days from the start of the project.

How do Vironova perform image analysis?
Our image analyses are performed using our proprietary Vironova Analyzer Software (VAS). VAS is a specialized software designed specifically for nanoparticle characterization using TEM as an analytical tool. It is an FDA 21 CFR Part 11 compliant software, ensuring compliance with our EM Services GMP certified services for TEM analytics.

How many days will it take for my sample to be analyzed?
We understand the importance of timely results, which is why your project will be performed during the reserved time slot. Our team will export images and prepare the report within 10 working days from the start of the project.  For AAV analyses, we offer an AAV Express service guaranteeing a delivery time of 4 working days from the receipt of your sample.

Why is it not possible for Vironova to use my buffer from one project to another, or even the same vial for different types of analyses?
As a GMP facility, we follow internal standard operating procedures to ensure good sample traceability. After analysis and the thawing process, any remaining samples and buffers are stored at 2-8°C or at room temperature for a maximum of 30 days. To avoid cross-contamination, we do not use buffers from one project for another project. We also do not recommend the use of the same sample vial for two different projects for the same reason. If you have a special request, please contact us and we will do our best to accommodate your needs.

Why is it so important that the sample submission form (SSF) is shipped together with our sample?
To ensure traceability between the sample shipment and the project, it is crucial that our team receives the Sample Submission Form (SSF) document along with the sample. The SSF document contains the unique project number for your project and can be traced back to the unique sample name. Therefore, it is essential that the SSF is submitted together with the sample.

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