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Unlock the Power of Comprehensive TEM Analysis with Vironova Bioanalytics

Make an informed decision for your product development with our all-inclusive GMP-certified TEM analysis package, featuring both negative stain and cryogenic methodologies. Our cutting-edge services cater to a diverse range of therapeutics nanoparticles, including:

  • AAV vectors
  • Adenovirus vectors
  • Lentiviral vectors
  • Liposomes and drug delivery systems
  • Extracellular vesicles
  • And more

Don't see your sample type listed? Reach out to our expert team for tailored TEM analysis solutions, designed to meet your unique needs. Discover the Vironova BIoanalytics difference today!

Two people working in our GMP certified laboratory.

An image from our GMP-certified TEM laboratory.

Accelerate Your Bioprocessing Project with AAV Express Service

In a hurry to advance your bioprocessing project?

Turn to Vironova's AAV Express service for a swift, guaranteed 4-business day turnaround time*, without sacrificing our renowned expertise and quality. Stay ahead of the competition and keep your project on track with our rapid, reliable AAV Express service AAV Express for your project

*counting from the first lab workday

Workflow AAV Express cropped

Extensive service portfolio

We offer an extensive service portfolio including a wide range of analyses (marked in red circle) to support your biopharma needs. We can also provide specific analyses tailored to your requirements.
 Viral vectors Type of analysis
  Overall morphology Size distribution Packaging Genome length Aggregation Circularity Integrity Customer-tailored particle classification Others
Adenoviral vectors    
Lentiviral vectors      
 Liposomes     Internal density assessment
 Lipid Nanoparticles (LNPs)     Lamellarity/Bilayer thickness
 Extracellular Vesicles (EVs)   Internal volume and density assessment
 Virus-like Particles (VLPs)       Internal density assessment
Modified Vaccinia Ankara (MVA)        
Vesicular Stomatitis Virus (VSV)         Elongatedness
Bacteriophages     Tail attachment
Immune Stimulating Complexes (ISCOMs)              
Inorganic nanoparticles         Aspect ratio


FAQ about our TEM services

What type of services do Vironova provide?
we offer a complete TEM analysis package that includes both negative stain TEM (nsTEM) and cryogenic TEM (cryo-TEM). Our analysis reports provide valuable morphological information that is translated into quantitative and qualitative data, allowing for faster and more informed decision-making.

What should I do to start a project with Vironova?
To learn more about our services and how we can assist you in the biopharma industry, please visit our website and fill out the "Send us a request" form, or email us directly at info@vironova.com. One of our team members will promptly contact you to set up a meeting with our experienced scientists who can explain our processes and answer any questions you may have.

What are the different steps in the process at Vironova when you start a project?
Once you have decided to utilize our services, we will begin the project by preparing the necessary documents according to our procedures. Once all documentation is complete, we will notify you that we are ready to receive your samples. Our delivery team will provide guidance to ensure that your samples are properly shipped to us. Our senior scientists in Stockholm will perform the analysis, and the analytical report will be finalized and delivered to you within 10-15 working days from the start of the project.

How do Vironova perform image analysis?
Our image analyses are performed using our proprietary Vironova Analyzer Software (VAS). VAS is a specialized software designed specifically for nanoparticle characterization using TEM as an analytical tool. It is an FDA 21 CFR Part 11 compliant software, ensuring compliance with our EM Services GMP certified services for TEM analytics.

How many days will it take for my sample to be analyzed?
We understand the importance of timely results, which is why your project will be performed during the reserved time slot. Our team will export images and prepare the report within 10 working days from the start of the project.  For AAV analyses, we offer an AAV Express service guaranteeing a delivery time of 4 working days from the receipt of your sample.

What is the required volume and particle concentration of the sample, in order to perform the TEM analysis?
To ensure accurate and reliable results, we require a minimum volume of 25 µL of sample and 2 mL of buffer, in case dilutions are necessary. The required sample concentration varies depending on the sample composition. For instance, adeno-associated virus (AAV) vectors require a concentration range between 1012-1013 viral particles per mL for TEM analysis. For more information on the required sample concentration for other types of samples, please click here.

Why is it not possible for Vironova to use my buffer from one project to another, or even the same vial for different types of analyses?
As a GMP facility, we follow internal standard operating procedures to ensure good sample traceability. After analysis and the thawing process, any remaining samples and buffers are stored at 2-8°C or at room temperature for a maximum of 30 days. To avoid cross-contamination, we do not use buffers from one project for another project. We also do not recommend the use of the same sample vial for two different projects for the same reason. If you have a special request, please contact us and we will do our best to accommodate your needs.

Why is it so important that the sample submission form (SSF) is shipped together with our sample?
To ensure traceability between the sample shipment and the project, it is crucial that our team receives the Sample Submission Form (SSF) document along with the sample. The SSF document contains the unique project number for your project and can be traced back to the unique sample name. Therefore, it is essential that the SSF is submitted together with the sample.

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If you have any questions or require further information about our electron microscopy services, please do not hesitate to contact us. We are happy to assist you in any way we can.

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