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From sample preparation to report

Vironova offers a complete GMP-certified TEM analysis package that includes both negative stain (nsTEM) analysis and cryogenic (cryoTEM) analysis, each providing powerful image datasets, quantitative data, and conclusions from the analysis.

There are a variety of nanoparticles that can be tested and analysed using TEM, at EM services we specialize in the following type of nanoparticles:

If you do not find your type of samples in the list above, please contact us. Our team of experts will suggest the type of TEM analysis suitable for your product.

Two people working in our GMP certified laboratory.

An image from our GMP-certified TEM laboratory.

Use our AAV Express service

Need to speed up your bioprocessing project timeline?

Our AAV Express service offers a guaranteed 4-business days turnaround time*, along with our signature expertise and quality.  

AAV Express for your project

*counting from first lab workday

Workflow AAV Express cropped

Visualization of analyses

Below you can find a visualization of our portfolio of analyzes by technique and analysis method.

TEM technique Analysis Type of particles
AAV vectors Adenovirus vectors Lentiviral vectors Liposomes and drug delivery systems Extracellular vesicles
nsTEM Sample morphology          
Aggregation     *   *
Particle size distribution          
CryoTEM Packaging analysis          
Thickness of bilayer          

*Analysis subjected to discussion with the client

FAQ about our TEM services

What type of services do Vironova provide?
We offer a complete TEM analysis package that includes both negative stain TEM (nsTEM) and cryogenic TEM (cryoTEM). Each analysis report provides useful morphological information that is translated into quantitative and qualitative data that aids in faster and informed decision.

What should I do to start a project with Vironova?
Please contact us through our website filling up the send us a request form or by email to info@vironova.com. One of our personnel will contact you to set up a meeting with our scientists who will explain our processes and answer your questions.

What are the different steps in the process at Vironova when you start a project?
When you decide to do a service with us, we will initiate the project by preparing the required documents according to our procedures. After all the documentation is completed, we will inform you that we can receive your samples. Our delivery team will guide you through properly shipping your samples. The analysis will be performed by our senior scientists in Stockholm and the analytical report will be finalized and sent to you within 10-15 working days after the project started.

How do Vironova perform image analysis?
All the image analyses provided by our services are performed using our proprietary software Vironova analyzer software (VAS). VAS was specifically designed and built to answer the needs of using TEM as an analytical tool for nanoparticle characterization. Moreover, the software is FDA 21 CFR Part 11 compliant being in accordance with our EM Services GMP certified services for TEM analytics.

How many days will it take for my sample to be analyzed?
Your project will be performed during the reserved time slot. Images and the report will be exported within 10-15 working days after the project started. For AAV analyses, we offer an AAV Express service guranteeing a delivery time of 4 working days from when we receive your sample.

What is the required volume and particle concentration of the sample, in order to perform the TEM analysis?
We require a minimum volume of 25 µL of sample and 2 mL of buffer, in case dilutions are needed. The sample concentration is dependent on different factors, particularly sample composition. As an example, adeno associated virus (AAV) vectors sample requires a concentration range between 1012-1013 viral particles per mL for TEM analysis. For more information on other type of samples please click here.

Why is it not possible for Vironova to use my buffer from one project to another, or even the same vial for different types of analyses?
Since we are a GMP facility we have internal standard operating procedures that ensure good sample traceability. After analysis and the thawing process, the remaining samples and buffers are stored at 2-8oC or at room temperature for a maximum of 30 days. To avoid cross-contamination we do not use the buffer from one project to another. For the same reason, we also do not recommend the use of the same sample vial for two different projects. Please contact us if you have a special request.

Why is it so important that the sample submission form (SSF) is shipped together with our sample?
The sample submission form (SSF) document shows the unique project number for your project, and can be traced back to the unique sample name. For this reason, it is of extreme importance that our team receives the SSF together with the sample. This ensures the traceability between the sample shipment and the project.

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Please contact us if you have any questions about the content on this page or anything else related to our electron microscopy services. 

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